CAUSAL EFFECT OF ATRIAL FIBRILLATION/FLUTTER ON CHRONIC KIDNEY DISEASE: A BIDIRECTIONAL TWO-SAMPLE MENDELIAN RANDOMIZATION STUDY.

Causal effect of atrial fibrillation/flutter on chronic kidney disease: A bidirectional two-sample Mendelian randomization study.

Chronic kidney disease (CKD) and atrial fibrillation are both major burdens on the health care system worldwide.Several observational studies have reported clinical associations between CKD and atrial fibrillation; however, causal relationships between these conditions remain to be elucidated due to possible bias by confounders and reverse causatio

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ATP11B inhibits breast cancer metastasis in a mouse model by suppressing externalization of nonapoptotic phosphatidylserine

Cancer metastasis is the cause of the majority of cancer-related deaths.In this study, we demonstrated that no expression or low PVC Heater Element expression of ATP11B in conjunction with high expression of PTDSS2, which was negatively regulated by BRCA1, markedly accelerates tumor metastasis.Further analysis revealed that cells with low ATP11B ex

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Systemic Governance of Mountains, Rivers, Forests, Farmlands, Lakes and Grasslands: Theoretical Framework and Approaches

The life community of mountains, rivers, forests, farmlands, lakes and grasslands (MRFFLG) and its systemic governance are key components to build ecological civilization in China.It comprises diverse connotations in value, scientific and economic dimensions.Epistemologically, it comes from the Chinese traditional philosophy of harmonious coexisten

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Nicotinamide adenine dinucleotide phosphate oxidase 2 deletion attenuates polyhexamethylene guanidine-induced lung injury in mice

Inhalation of polyhexamethylene guanidine phosphate (PHMG) can cause pulmonary fibrosis.Nicotinamide adenine dinucleotide phosphate (NADPH) oxidases (Nox) are enzymes that produce reactive oxygen species, which may be involved in tissue damage in various Grille Guard lung diseases.To investigate whether the Nox2 isoform of Nox is involved in the pr

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